How to fix Remote I/O error while connecting to adafruit MPR 121 on Raspberry Pi Zero?

  adafruit, python, raspberry-pi

I have been trying to connect Adafruit MPR 121 to Raspberry Pi Zero. I have connected it as follows:
GPIO 2 – SDA, GPIO 3 – SCL, 3.3V – VIN, GND – GND (upper one).

I have enabled I2c via raspi-config.
Initialization looks like that:

cap = MPR121.MPR121()
if not cap.begin():
    print('Error initializing MPR121.  Check your wiring!')

At first, the code was working and I2C has successfully connected and it was possible to touch some pins and receive output.
sudo i2cdetect -y 0 was showing that it was connected on address 0x5a. Now I get an error:

Traceback (most recent call last):
  File "/home/pi/", line 303, in <module>
  File "/home/pi/", line 53, in init
    if not cap.begin():
  File "/usr/local/lib/python3.9/dist-packages/Adafruit_MPR121/", line 93, in begin
    return self._reset()
  File "/usr/local/lib/python3.9/dist-packages/Adafruit_MPR121/", line 97, in _reset
    self._i2c_retry(self._device.write8, MPR121_SOFTRESET, 0x63)
  File "/usr/local/lib/python3.9/dist-packages/Adafruit_MPR121/", line 140, in _i2c_retry
    raise ex
  File "/usr/local/lib/python3.9/dist-packages/Adafruit_MPR121/", line 136, in _i2c_retry
    return func(*params)
  File "/usr/local/lib/python3.9/dist-packages/Adafruit_GPIO/", line 114, in write8
    self._bus.write_byte_data(self._address, register, value)
  File "/usr/local/lib/python3.9/dist-packages/Adafruit_PureIO/", line 327, in write_byte_data
OSError: [Errno 121] Remote I/O error

It was appearing rarely before, but now I get it every single time.
Moreover, sudo i2cdetect -y 1 doesn’t show any connected devices.
I’ve checked wiring and it looks good to me.

Source: Python Questions